AeroLab Reading room

Biology / AS level

Transport in mammals and the heart

The cardiac cycle coordinates atrial and ventricular contraction with pressure-sensitive valves.

Learning objectives

The big idea

The cardiac cycle coordinates atrial and ventricular contraction with pressure-sensitive valves. Electrical excitation begins in pacemaker tissue and spreads through a conduction system; valves open because of pressure differences rather than active pulling.

Haemoglobin’s cooperative oxygen binding supports loading at high oxygen partial pressure and unloading in respiring tissues. Carbon dioxide is transported mainly after conversion to hydrogencarbonate, with additional dissolved and haemoglobin-associated forms. Vessel structure matches pressure, return and exchange roles.

Worked example

Heart rate is 70 beats/min and stroke volume is 70 cm³/beat. Find cardiac output.

Follow the solution

Multiply rate by volume per beat: 70×70=4900 cm³/min, or 4.9 dm³/min.

Investigate and explain

Using the worked example as supplied data, predict the effect of changing one condition. Draw a labelled model, record your reasoning and identify a variable that would need controlling. No human, animal or microbial experiment is required.

No exact PhET model is claimed for this topic. Use diagrams and supplied-data reasoning instead.

Open the interactive investigation

Check your understanding

1. What opens a heart valve?

  1. A command sent directly to the valve leaflets
  2. Oxygen binding to plasma
  3. An appropriate pressure difference
Check the answer and reasoning

An appropriate pressure difference

Valve movement responds passively to pressures on its two sides.

2. Heart rate is 70 beats/min and stroke volume is 70 cm³/beat. Find cardiac output.

  1. 4900 cm³/min
  2. 1 cm³/min
  3. 140 cm³/min
Check the answer and reasoning

4900 cm³/min

Multiply rate by volume per beat: 70×70=4900 cm³/min, or 4.9 dm³/min.

3. Does a haemoglobin molecule always retain all bound oxygen until it reaches a vein?

  1. Yes
  2. No
  3. Only at rest
Check the answer and reasoning

No

Oxygen loading and unloading respond to local partial pressure and conditions, especially in exchanging tissues.